Sebastian Kehrlößer, Curriculum Vitae

Academic Positions & Education

2016-current Research Associate, University of Cambridge, Cancer Research UK, Cambridge Institute, Cambridge, UK
2011-2015 Ph.D. in Biochemistry, Goethe University Frankfurt, Frankfurt, Germany
2005-2010 Diploma (Masters) in Biochemistry, Goethe University Frankfurt, Frankfurt, Germany



[7] Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

D Coutandin, C Osterburg, RK Srivastav, M Sumyk, S Kehrloesser, J Gebel, M Tuppi, J Hannewald, B Schafer, E Salah, S Mathea, U Muller-Kuller, J Doutch, M Grez, S Knapp, V Dotsch

eLife 5(), (2016)

[6] Structural Evolution and Dynamics of the p53 Proteins

G Chillemi, S Kehrloesser, F Bernassola, A Desideri, V Dotsch, AJ Levine, G Melino

Cold Spring Harbor perspectives in medicine (), a028308 (2016)

[5] Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family

S Kehrloesser, C Osterburg, M Tuppi, B Schafer, KH Vousden, V Dotsch

Cell death and differentiation 23(12), 1952--1960 (2016)


[4] Functional interplay between MDM2, p63/p73 and mutant p53

MH Stindt, PAJ Muller, RL Ludwig, S Kehrloesser, V Dotsch, KH Vousden

Oncogene 34(33), 4300--10 (2015)


[3] Analysis of the oligomeric state and transactivation potential of TAp73$\alpha$

LM Luh, S Kehrloesser, GB Deutsch, J Gebel, D Coutandin, B Schafer, M Agostini, G Melino, V Dotsch

Cell death and differentiation 20(8), 1008--16 (2013)


[2] The Apaf-1-binding protein Aven is cleaved by Cathepsin D to unleash its anti-apoptotic potential

IM Melzer, SBM Fernandez, S Bosser, K Lohrig, U Lewandrowski, D Wolters, S Kehrloesser, M Brezniceanu, AC Theos, PM Irusta, F Impens, K Gevaert, M Zornig

Cell death and differentiation 19(9), 1435--45 (2012)

[1] Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

P Tucci, M Agostini, F Grespi, EK Markert, A Terrinoni, KH Vousden, PAJ Muller, V Dotsch, S Kehrloesser, BS Sayan, G Giaccone, SW Lowe, N Takahashi, P Vandenabeele, RA Knight, AJ Levine, G Melino

Proceedings of the National Academy of Sciences of the United States of America 109(38), 15312--7 (2012)